Wine in Hippocratic medicine was considered an effective means of therapy.  Hippocrates (circa 460-360 BC), known as the “Father of Medicine”, had researched the nature of wine and had written down the guidelines as to the manner in which wine should be used. He recommended that water be mixed with wine (kekramenos oenos), so as it may ward off the seditious effect of microorganisms. His philosophical education and profound knowledge on therapeutic treatment led him to encourage moderate consumption of wine under certain conditions -which is in general endorsed by the medical scientific community today.